Crossroads Podcast is the best Supernatural podcast in my opinion! Hosts Ty and Star have scheduled a live show on the 24th November 7pm US central time. I couldn't make it to the first live show, but I am definitely going to be there this time and meet the Crossroads nation!
If you want to join, go to uStream. If this link doesn't work, just search for 'Crossroads Podcast'.
You can listen to Crossroadscast on iTune. Follow them on Twitter or join them on Facebook.